Effect of sitaxsentan on renal microcirculation in beagle dogs undergoing cardiopulmonary bypass:mornitoring using ultrasound microbubble angiography
10.3760/cma.j.issn.0254-1416.2017.03.010
- VernacularTitle:西他生坦对体外循环犬肾微循环的影响:超声微泡造影术监测
- Author:
Yiping BAI
;
Li LIU
;
Ni TANG
;
Yabing ZHANG
;
Bin LIU
- Keywords:
Kidney;
Microcirculation;
Cardiopulmonary bypass;
Ultrasonography;
Endothelin receptor antagonist
- From:
Chinese Journal of Anesthesiology
2017;37(3):292-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of sitaxsentan on renal microcirculation in beagle dogs undergoing cardiopulmonary bypass(CPB)when ultrasound microbubble angiography was used to monitor renal microcirculation.Methods Eighteen male Beagle dogs,weighing 10-15kg,aged 2-4 yr,were allocated into 3 groups(n=6 each)using a random number table:sham operation group(Sham group),CPB group and sitaxsentan group(S group).Sitaxsentan 0.7 mg/kg was infused over 30min starting from 1 h before CPB in group S.Before CPB(T1),at 1 h of CPB(T2),at the end of CPB(T3)and at 2h after the end of CPB(T4),the time-intensity curve of renal parenchyma perfusion was obtained using ultrasound microbubble angiography,and quantitative parameters including the slope rate of ascending curve(A),area under curve(AUC),derived peak intensity(DPI)and time to peak(TTP)were fitted.Results Compared with Sham group,the value of A was significantly decreased at T2-4,AUC and TTP were increased at T3,4,DPI was decreased at T4 in renal cortex and medulla in CPB group,and the value of A was significantly decreased and TTP was increased at T2-4,AUC was increased at T3,4(P<0.05),and no significant change was found in DPI in renal cortex and medulla in S group(P>0.05).Compared with CPB group,the value of A was significantly increased and AUC and TTP were decreased at T3,4 in renal cortex and medulla(P<0.05),and no significant change was found in DPI in renal cortex and medulla in group S(P>0.05).Conclusion Sitaxsentan can improve renal microcirculation in beagle dogs undergoing CPB.
