miR-27a rs895819 and lnc-LRFN2-2 rs61516247 polymorphism could increase risk of kidney transplantation rejection

VernacularTitle:miR-27a和lnc-LRFN2-2基因多态性与移植肾排斥反应发生风险的相关性研究
Author: Bengang WANG ; Zhi LYU ; Qian XU ; Liping SUN ; Lei YANG ; Hao LIU ; Yongfeng LIU
Keywords: Kidney transplantation; Polyrmorphism; single nucleotide; Graft rejection
From: Chinese Journal of Organ Transplantation 2016;37(12):726-730
CountryChina
Language:Chinese
Abstract: Objective To explore whether polymorphisms in non-coding RNA has potential as biomarkers for predicting the risk of kidney transplantation rejection.Methods A total of 79 patients who had received kidney transplants were recruited from the First Affiliated Hospital of China Medical University and divided into the rejection group (n =26) and non-rejection group (n =53).Four polymorphisms in miRNA and 8 polymorphisms in lncRNA were detected by MALDI-TOF-MS.Results When compared with the wild genotype,the mutation genotype in miR-27a rs895819 and lnc-LRFN2-2 rs61516247 had 11.72 and 4.87 folds increased risk of kidney transplantation rejection (P =0.046,OR=1.04-131.74 and P =0.047,95％ CI =1.02-23.21,respectively).The other three polymorphisms in miRNA and 7 polymorphisms in lncRNA showed no significant associations with transplantation rejection risk (P ＞ 0.05).Conclusion The miR-27a rs895819 and lnc-LRFN2-2 rs61516247 polymorphisms were associated with the risk of kidney transplantation rejection.