Clinicopathological characteristics of adenoid cystic carcinoma of the breast: an analysis of 3 cases

VernacularTitle:乳腺腺样囊性癌临床病理特点
Author: Jingping YUAN ; Honglin YAN ; Hao WU ; Likun GAO ; Jie RAO ; Jichang HU ; Xiuxue YUAN
Keywords: Breast; Adenoid cystic carcinoma; Clinical pathology; Immunohistochemisty
From: Chinese Journal of Endocrine Surgery 2017;11(2):107-109,126
CountryChina
Language:Chinese
Abstract: Objective To explore the clinicopathological features and diagnosis of adenoid cystic carci noma of the breast (ACCB).Methods Clinical data of 3 cases of ACCB were collected and followed up to observe the clinical pathological features.Immunohistochemistry was used to determine the immune phenotype.Results All the 3 cases were female,aging from 55 to 72 years old (61 years old as the average).The tumors were found in subareolar region well-circumscribed.ACCB was characterized by the presence of a dual cell population of luminal and basaloid cells arranged in cribriform and tubular-trabecular patterns.On immunohistochemical staining,the myoepithelial cells expressed SMA,CK5/6,P63,CD117 and the glandular epithelium cells were mostly positive for CK18,EMA,CK7,while no expression of ER,PR,HER-2,CD10 was observed.Conclusions ACCB is a rare neoplasm with a triple-negative,basal-like phenotype,but exhibits an indolent clinical behavior.The diagnosis can be worked out by evaluation of clinical characterstics,histological and immunohistochemical features.