Clinicopathologic characteristics and prognosis of medullary breast carcinoma
10.3760/cma.j.issn.1007-631X.2017.03.007
- VernacularTitle:乳腺髓样癌临床病理特征及预后分析
- Author:
Kun MU
;
Zizheng WU
;
Haifei NIU
;
Nan WU
;
Jing ZHAO
;
Jun ZHANG
;
Juntian LIU
- Keywords:
Breast neoplasms;
Pathology;
clinical;
Molecular types;
Prognosis
- From:
Chinese Journal of General Surgery
2017;32(3):211-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathologic characteristics and prognosis of medullary breast carcinoma.Methods We conducted a retrospective analysis on clinical and pathologic data of 166 patients with medullary breast cancer.Results All the patients were female with a median age of 52 years old.The proportion of patients with stage Ⅰ,Ⅱ and Ⅲ disease was 16.9％,68.1％,15.0％,respectively.The Luminal,HER-2 overexpressing and triple-negative subtypes constituted 31.3％,8.4％,and 60.3％,respectively.There was significant difference in regional lymph node status of medullary breast cancer patients with different molecular types (x2 =18.248,P =0.003),but not in tumor size,TNM stage,histological grade,and expression of Ki67 (all P ＞ 0.05).Multivariate survival analysis indicated that TNM stage was an independent predictor in the prognosis of medullary breast cancer (HR =5.664,P =0.001).All the patients were followed up from 15 months to 145 months with a median follow-up time of 108 months.The 5-year survival rate was 91.5％ and the 10-year survival rate was 87.2％.Conclusions The prognosis of medullary breast cancer is favorable.Personalized treatment according to the TNM stage and histopathologic characteristics achieve a favorable prognosis.
