The expression of FZD7 and IL-6 in primary hepatocellular carcinoma and the impact on the prognosis
10.3760/cma.j.issn.1007-631X.2017.03.019
- VernacularTitle:卷曲同源蛋白7和白细胞介素6在肝细胞癌中的表达及对预后的影响
- Author:
Ke CHEN
;
Bo CHEN
;
Liyu CAO
;
Maoming XIONG
- Keywords:
Carcinoma;
hepatocellular;
Interleukin-6;
Frizzled homolog protein 7
- From:
Chinese Journal of General Surgery
2017;32(3):251-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of FZD7 (frizzled homolog protein7,FZD7) and IL-6 (interleukin-6,IL-6) in primary hepatocellular carcinoma(HCC) and the impact on the prognosis.Methods Immunohistochemistry(IHC) was used to detect the expression level of FZD7 and IL-6 in 68 HCC tissues,30 para-carcinoma tissues and 10 healthy controls from patients with hepatic hemangioma.Patients were followed-up for survival analysis.Results The expression ratio of FZD7 in HCC tissue,paracarcinoma tissue and healthy controls were 72%,53% and 0 (P < 0.001),the ratio of IL-6 expression was respectively 69%,57% and 0 (P <0.001).The expressions of FZD7 were positively correlated with that of AFP level (x2 =7.059,P =0.035),pathology classification (x2 =4.732,P =0.043),and the infection of HBs (x2 =3.508,P =0.032).The overall survival (65 % vs.84%,x2 =5.525,P < 0.05) and the disease free survival (33% vs.75%,x2 =5.991,P <0.05) of HCC patients with co-positive was significantly lower than that with co-negative expression of FZD7 and IL-6.Conclusion FZD7 and IL-6 play a critical role in development and progression of HCC.