Research progress on the molecular biomarkers for patients with hepatocellular carcinoma recurrence after surgery
10.3760/cma.j.issn.1007-8118.2017.04.018
- VernacularTitle:肝癌患者术后复发分子标志物的临床研究进展
- Author:
Chaohui XIAO
;
Rong LIU
- Keywords:
Hepatocellular carcinoma;
Tumor recurrence;
Molecular biomarker
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(4):277-281
- CountryChina
- Language:Chinese
-
Abstract:
Tumor recurrence is the main factor affecting the postoperative prognosis of hepatocellular carcinoma.The forecast of tumor recurrence by monitoring biomarker can effectively improve the prognosis of such disease.To improve the detection rate of early cancer recurrence can be achieved by detecting the level of the alpha-fetoprotein (AFP),Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3),des-γ-carboxyprothrombin (DCP),or combined detection.In recent years,the researches on the miRNA and Long Noncoding RNAs (LncRNA),which are key regulators in the upstream of signal pathways,could provide a new way for HCC recurrence monitoring.The combined detection of biomarkers in different control levels,maybe is the effective measure to improve the tumor recurrence detection rate,and is also the focus of the further research.
