Clinical Observation of Gegen Decoction Plus Sini Powder for Treatment of Polycystic Ovarian Syndrome Women with Acne
10.13359/j.cnki.gzxbtcm.2017.03.009
- VernacularTitle:葛根汤合四逆散治疗多囊卵巢综合征型痤疮临床疗效观察
- Author:
Lifen OU
;
Yingxuan ZHANG
;
Ying ZHOU
- Keywords:
Gegen Decoction;
Sini Decoction;
polycystic ovary syndrome;
acne;
Diane-35;
dihydrotesterone;
interleukin-6;
interleukin-8
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(3):335-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of Gegen Decoction plus Sini Powder for polycystic ovarian syndrome(PCOS) women with acne and to explore its possible therapeutic mechanism.Methods Seventy cases of PCOS women with acne aged 18-45 years were randomized into treatment group and control group,35 cases in each group.The treatment group was given Gegen Decoction plus Sini Powder orally and the control group was given Diane-35 orally.The treatment lasted for 12 weeks.After treatment,the skin lesions and symptom scores were observed.The body mass index (BMI),serum dihydrotestosterone (DHT),interleukin-6 (IL-6) and interleukin-8 (IL-8) were detected before and after treatment.Results (1) The markedly effective rate of the treatment group was 80.00％ and that of the control group was 57.14％,the difference being significant between the two groups(P ＜ 0.05).(2) After treatment,the total scores of the symptoms and the scores of each symptom such as sweating,sleeping and physical strength in both groups were decreased(P ＜ 0.01),and the decrease in the treatment group was superior to that in the control group(P ＜ 0.05).(3) The BMI and serum levels of DHT,IL-6 and IL-8 in both groups were significantly decreased after treatment (P ＜ 0.01),and the decrease in the treatment group was superior to that in the control group(P ＜ 0.05).Conclusion Gegen Decoction plus Sini Powder is effective for the treatment of PCOS women with acne,and the mechanism is probably related with the decrease of BMI and serum DHT,IL-6 and IL-8 levels.
