Tomography Study on Total Flavonoids from Rhizoma Drynariae in Promoting New Bone Formation in Distraction Osteogenesis Rat Model
10.13359/j.cnki.gzxbtcm.2017.03.022
- VernacularTitle:骨碎补总黄酮促进大鼠牵张成骨新骨形成的影像学研究
- Author:
Ziwei JIANG
;
Jingqi ZENG
;
Feng HUANG
;
Fan WANG
;
Yue LI
;
Qunsheng HU
;
Zhikui ZENG
;
Xiang YU
;
Haifeng ZHU
- Keywords:
distraction osteogenesis;
total flavonoids from Rhizoma Drynariae;
tomography;
disease models,animal;
rats
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(3):390-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a distraction osteogenesis SD rat model for exploring the effect of total flavonoids from Rhizoma Drynariae on the quality of rat bone formation in the process of distraction osteogenesis from the perspective of tomography.Methods Twenty-four rats were randomly divided into experimental group and control group after successful modeling,and were respectively given intragastric administration with total flavonoids from Rhizoma Drynariae(in dose of 77.125 mg/kg) and saline for 8 weeks.Seven days after operation,the tibias of all the rats were given distraction at the speed of 0.2 mm for 20 days.Eight weeks after the operation,X-ray examination for all the rats was performed,and then the rats were killed for obtaining the tibia samples for Micro-CT scanning.The differences of X-ray Lane-Sandhu scores,the bone mineral density and bone mineral content were compared between the two groups.Results The X-ray Lane-Sandhu scores,the bone mineral density and bone mineral contents showed by Micro-CT scanning in the experimental group were higher than those in the control group,and the differences were statistically significant (P ＜ 0.05).Conclusion The total flavonoids from Rhizoma Drynariae can improve the quality of bone formation in the process of distraction osteogenesis in rats.
