Associations of IL-6/IL-6R polymorphisms with the risk of gastric cancer in Xuyi region of Huai'an
10.13602/j.cnki.jcls.2017.03.08
- VernacularTitle:IL-6/IL-6R基因多态性与淮安盱眙地区胃癌发病风险的相关性研究
- Author:
Jun XIE
;
Ling CHU
;
Juan LIU
- Keywords:
gastric cancer;
IL-6;
IL-6R;
gene polymorphism
- From:
Chinese Journal of Clinical Laboratory Science
2017;35(3):184-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations of IL-6(rs6949149,rs1800796 and rs10499563) and IL-6R(rs2228145) single nucleotide polymorphisms(SNP) with the risk of gastric cancer in Chinese Han population of Xuyi,Huai'an.Methods A total of 400 patients with gastric cancer and 400 healthy controls were enrolled in this case-control study.The genotypes of the four SNPs were detected by the Mass-Array technology.The associations between the IL-5/IL-6R SNPs and the risk of gastric cancer were analyzed by Logistic regression model.Results There was a significant difference in the distribution of the IL-6 rs1800796 genotypes between the patients with gastric cancer and healthy controls(x2 =6.213,P =0.045).The IL-6 rs1800796 GG genotype was associated with a increased risk of gastric cancer(adjusted OR =1.27,95 ％ CI:1.15-3.20,x2 =6.326,P =0.012).Subgroup analysis showed that the associations between the IL-6 rs1800796 GG genotype and the risk of gastric cancer were obvious in the female(adjusted OR =3.99,95％ CI:1.36-11.71,x2 =6.358,P =0.012) and the patients with H.pylori infection(adjusted OR =2.20,95％ CI:1.08-4.45,x2 =4.770,P =0.029).Conclusion The IL-6 rs1800796 GG geuotype is associated with the risk of gastric cancer,especially in the female and the patients with H.pylori infection.
