Differential Expression of Plasma Protein Profile in Patients with Kidney-yin Deficiency Syndrome
10.13359/j.cnki.gzxbtcm.2017.03.002
- VernacularTitle:肾阴虚证血浆蛋白质谱的差异表达
- Author:
Jianlu BI
;
Min WEI
;
Xiaomin SUN
;
Xiaoli NIE
;
Ya XIAO
;
Wei MO
;
Xiaoshan ZHAO
;
Ren LUO
- Keywords:
kidney-yin deficiency syndrome;
TCM syndromes;
proteomics;
chips
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(3):308-313
- CountryChina
- Language:Chinese
-
Abstract:
Objective To seek for the differentially-expressed proteins in patients with kidney-yin deficiency syndrome and to screen out the specific proteins,so as to provide evidence for the establishment of objective standard of kidney deficiency syndrome of traditional Chinese medicine (TCM).Methods Five patients with typical kidney-yin deficiency syndrome and 6 normal healthy volunteers were enrolled into the study.Plasma proteins in both groups were detected by antibody chip,and then the plasma proteins profile was compared and analyzed.Results A total of 25 differentially-expressed proteins between kidney-yin deficiency group and normal control group were found,of which 2 were up-regulated and 23 were down-regulated.Conclusion The differentially-expressed proteins in patients with kidney-yin deficiency syndrome are mainly related to immune disorder,protein biosynthesis,metabolism,oxidative stress,cell apoptosis,signal transduction,and so on.
