Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude.
10.3341/jkos.2014.55.6.854
- Author:
Se Ran JANG
1
;
Mar Vin LEE
;
Jae Hong AHN
Author Information
1. Department of Ophthalmology, Ajou University Medical Center, Ajou University School of Medicine, Suwon, Korea. chrisahn@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Dorzolamide-timolol fixed combination;
Dynamic contour tonometer;
Intraocular pressure;
Latanoprost;
Ocular pulse amplitude
- MeSH:
Glaucoma;
Glaucoma, Open-Angle;
Humans;
Intraocular Pressure*
- From:Journal of the Korean Ophthalmological Society
2014;55(6):854-859
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare dorzolamide-timolol fixed combination (DTFC) and latanoprost with regard to their effects on intraocular pressure (IOP) and ocular pulse amplitude (OPA). METHODS: Sixty eyes of 60 patients with open angle glaucoma or glaucoma suspect were included in the present study. Patients were divided into 2 groups, DTFC-treated (n = 30) and latanoprost-treated (n = 30). IOP and OPA were measured with dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT), before and at least 1 month after treatment. RESULTS: GAT IOP, DCT IOP and OPA decreased by 2.25 +/- 2.23 mm Hg, 1.97 +/- 2.06 mm Hg, and 0.14 +/- 0.88 mm Hg, respectively in the DTFC-treated group. In the latanoprost-treated group, GAT IOP, DCT IOP and OPA was reduced by 2.74 +/- 2.96 mm Hg, 2.06 +/- 3.50 mm Hg, and 0.69 +/- 1.07 mm Hg, respectively. There was no significant difference (p = 0.311) in the decline of IOP between the 2 groups, but OPA of the DTFC-treated group decreased less than the latanoprost-treated group (p = 0.032). CONCLUSIONS: No significant differences were observed in the short-term decline of IOP between the 2 medications. However, the influence of DTFC on OPA appeared negligible in the latanoprost-treated group.
