Association of Toll-Like Receptor Gene with Crohn's Disease in Koreans.
10.4166/kjg.2009.54.6.377
- Author:
Byong Duk YE
1
;
Suk Kyun YANG
;
Kyuyoung SONG
;
Dong Hoon YANG
;
Soon Man YOON
;
Kyung Jo KIM
;
Jeong Sik BYEON
;
Seung Jae MYUNG
;
Jin Ho KIM
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. sky@amc.seoul.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Crohn's disease;
Toll-like receptor;
Korea
- MeSH:
Adolescent;
Adult;
Alleles;
Asian Continental Ancestry Group/*genetics;
Crohn Disease/diagnosis/ethnology/*genetics;
Female;
Genetic Predisposition to Disease;
Genotype;
Humans;
Male;
Republic of Korea;
Toll-Like Receptor 4/*genetics;
Toll-Like Receptor 9/*genetics
- From:The Korean Journal of Gastroenterology
2009;54(6):377-383
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Toll-like receptors (TLRs) serve as pattern recognition receptors that recognize specific molecular patterns of pathogens and can mediate the production of proinflammatory cytokines. Recently, TLRs have been identified as susceptibility genes for Crohn's disease (CD) in several studies from Western populations. We investigated the association of genetic variations in TLR4 and TLR9 with CD in Korean population. METHODS: In 380 CD cases and 380 healthy controls, we performed genotyping for TLR4 Asp299Gly (rs4986790) and Thr399Ile (rs4986791). The genetic variations in the TLR9 -1237T/C (rs5743836) were also examined. RESULTS: Among CD patients genotyped for TLR4 Asp299Gly and TLR9 -1237T/C, none had variant alleles. Similarly, none of the subjects genotyped for TLR4 Thr399Ile showed genetic variations. CONCLUSIONS: Our results indicate that the major genetic variations in TLR4 and TLR9 are rare and may not be associated with susceptibility to CD in Koreans.
