Analysis of Influential Factors for Potential Drug-drug Interaction-induced Adverse Drug Event in Elder Patients of Cardiovascular Department from Our Hospital

VernacularTitle:我院心血管内科老年患者潜在药物相互作用导致药物不良事件的影响因素分析
Author: Chaofeng LIAO ; Lüzhao ZHANG ; Yingzhen LIU
Keywords: Drug-drug interaction; Adverse drug event:Multivariate Logistic regression; Cardiovascular department
From: China Pharmacy 2017;28(14):1924-1927
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To provide reference for reducing disadvantageous drug-drug interaction(DDI)and avoiding adverse drug event(ADE). METHODS: The patients aged more than 65 were selected from cardiovascular department in our hospital dur-ing Jun. 2015-Mar. 2016. The influential factors for potential DDI(PDDI)-induced ADE were analyzed. The relationship of related factors with PDDI-induced ADE was analyzed by multivariate Logistic regression analysis. RESULTS:A total of 328 patients were included,involving 257 PDDI patients,and totally 452 cases of PDDI (including 247 cases of mild PDDI,149 cases of general PDDI and 56 cases of severe PDDI). The age,the number of drugs used simultaneously,Ccr and liver function (Child-Pugh score)were related to the occurrence of PDDI-induced ADE(P<0.01). CONCLUSIONS:For PDDI-induced ADE,the risk evalua-tion can be conducted for a series of factors,including age,the number of drugs used simultaneously,Ccr and liver function. For high-risk patients,intervene should be conducted in advance to reduce the risk of ADE.