Analysis of 727 ADR Reports of Tinkgo Leaf Extract and Dipyridamole Injection
10.6039/j.issn.1001-0408.2017.14.16
- VernacularTitle:727例银杏达莫注射液不良反应报告分析
- Author:
Hongxia LI
;
Meiling XU
;
Kailan MA
;
Ke WANG
- Keywords:
Ginkgo leaf extract and dipyridamole injection;
ADR;
Literature analysis
- From:
China Pharmacy
2017;28(14):1931-1933
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the characteristics and general rule of ADR induced by Ginkgo leaf extract and dipyri-damole injection,and to provide reference for clinical rational drug use. METHODS:UsingGinkgo leaf extract and dipyridamole injectionADRas subject,the journal articles were retrieved from CJFD during Jan. 1st,2005-Jun. 28th,2016,and then ana-lyzed statistically in respects of gender,age,primary disease,allergic disease,drug use,occurrence time of ADR,organs/systems involved and clinical manifestations. RESULTS:A total of 14 valid articles had been collected,involving 727 patients in total. Meanwhile,female was more than male(57.63% vs. 42.37%)and most of them aged more than 50 years;primary diseases were mainly thromboembolic disease and coronary heart disease;most of ADR happened within 30 min after medication (268 cases, 36.86%). Organs/systems involved in ADR were mainly nervous system (254 cases,28.60%),followed by skin and its appen-dants(228 cases,25.68%),digestive system(187 cases,21.06%);severe ADR could cause anaphylactic shock. There were 18 cases of new severe ADR (2.48%);all ADR cases were recovered,and no death occurred. CONCLUSIONS:It is suggested to strictly control indications,differential diagnosis and treatment,rational drug use,close monitoring through the whole process, maintain a high level of awareness to ADR.
