BOLD MRI in evaluation of renal oxygenation in primary nephrotic syndrome
10.13929/j.1003-3289.201611115
- VernacularTitle:BOLD MRI评价原发性肾病综合征的肾内氧代谢状态
- Author:
Rui ZHANG
;
Wenbo XIAO
;
Qidong WANG
;
Zhaoming WANG
- Keywords:
Kidney;
Blood oxygen level dependent;
Magnetic resonance imaging;
Pathology;
Prognosis
- From:
Chinese Journal of Medical Imaging Technology
2017;33(9):1388-1391
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the renal oxygenation in patients with primary nephrotic syndrome (PNS) using BOLD MRI.Methods Twenty patients with untreated first-onset PNS and 18 healthy control subjects underwent BOLD MRI.The R2* of renal cortex and medulla were measured.Blood and urine samples were obtained on the day of MRI,and the patients underwent renal biopsy after MRI.The renal tubulointerstitial damage scores (TIDS) were determined using Katafuchi criteria.All patients received corticosteroids within 7 days after MRI and were followed up for 12 months.The difference of R2* levels between the PNS patients and controls were compared,and the correlations between R2* values and TIDS,laboratory parameters (eGFR,etc.) were tested.Results R2* values of renal medulla in PNS patients significantly decreased compared that of the controls (t =-9.270,P＜0.001).R2* values of renal medulla in PNS patients were negatively correlated with eGFR (r=-0.462,P=0.040) and positively correlated with TIDS (r=0.809,P＜0.001).There was a slight tendency for higher R2* values of renal medulla in individuals with poor prognosis.Conclusion BOLD MRI is a noninvasive method for the detection of renal oxygenation changes,which can evaluate the renal function and tubulointerstitial impairment,as well as prediction of the prognosis for PNS patients.
