Effect of postoperative analgesia with oxycodone on T cell function after operative of cesarean section with chronic hepatitis B
- VernacularTitle:羟考酮对慢性乙型肝炎剖宫产产妇术后T细胞功能的影响
- Author:
Jia WANG
;
Xiaodong QIU
;
Guoping YIN
- Keywords:
Oxycodone;
Cesarean section;
Chronic hepatitis B;
Immune function
- From:
The Journal of Clinical Anesthesiology
2017;33(9):878-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of postoperative analgesia with oxycodone on T cell function after operative of cesarean section with chronic hepatitis B.Methods Sixty cesarean sec-tion women with chronic hepatitis B undergoing CS,aged 22-35,were randomly divided into two groups:oxycodone group (group O)and morphine group (group M).The changes of immune cells (Th1,Th2)and liver function were recorded after the analgesia (immediate,postoperative 24 h,48 h,72 h).The total number of pressing analgesia pump and the cumulative amount of PCA were re-corded.Results The Th1 of group O was higher than that of group M at 24 h,48 h after operation (P <0.05),while there was no significant difference of Th1 and Th2 in group M.The total patient-controlled pressing times and accumulated amount of PCA of group O were significantly lower than those in group M (P <0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Oxycodone can activate T cell function in postoperative analge-sia,while morphine causes the inhibition of Th1 cells.
