Efficacy analysis of ketamine on the patients with depression of modified electric convulsive therapy
- VernacularTitle:氯胺酮在抑郁症患者无抽搐电休克治疗中的疗效分析
- Author:
Fengmei MEI
;
Wei YUE
;
Qiong ZENG
;
Shanshan WU
;
Xiaoning GAO
;
Meihua ZHU
- Keywords:
Ketamine;
Modified electric convulsive therapy;
Depression
- From:
The Journal of Clinical Anesthesiology
2017;33(9):864-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of ketamine on the patients with depression re-ceiving modified electric conulsive therapy (MECT).Methods Sixty patients with depression were randomly divided into ketamine group and propofol group (n =30 each group).Atropine 0.5-1.0 mg, propofol 1.0 mg/kg or ketamine 0.8 mg/kg i.v.were given before MECT,Scoline 0.7-1.0 mg/kg i. v.was given after the eyelash reflex disappeared.Hamilton Depression Rating Scale (HAMD)was completed after the 2 nd ,4 th and 6 th MECT,the time of convulsion,twitch index,energy percentage, respiratory recovery time and adverse reactions were recorded.Results The total score of HAMD was significantly decreased with the increasing times of MECT in both groups,compared with propo-fol group,ketamine group's HAMD total score decreased faster,especially after the 4th MECT,the score decreased significantly in ketamine group (P <0.05).The time of convulsion,twitch index,en-ergy percentage, respiratory recovery time, adverse reactions all had no statistical significance between the two groups.Conclusion Compered with propofol,ketamine,as an anesthetic of MECT, can effectively lower the score of HAMD.
