Research progress of endothelial progenitor cells therapy for therapeutic angiogenesis in the elderly with ischemic heart disease
10.3760/cma.j.issn.0254-9026.2017.09.028
- VernacularTitle:内皮祖细胞在老年缺血性心脏病血管新生治疗中的研究进展
- Author:
Kun WANG
;
Shengshuai SHAN
;
Chengyun LIU
- Keywords:
Endothelial cells;
Aging;
Myocardial ischemia
- From:
Chinese Journal of Geriatrics
2017;36(9):1049-1053
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic heart disease (IHD) is a serious threat to health of the elderly,and endothelial progenitor cells therapy-induced therapeutic angiogenesis can improve vascular reperfusion and functional recovery in ischemic myocardium.Endothelial progenitor cell (EPC) therapy plays an important role in endothelial repair and postnatal angiogenesis.And the concept of EPC therapy has received attention.EPC population is decreased in numbers and in functional activity,which are correlated with age and cardiovascular risk factor.And patients with these backgrounds have less therapeutic benefit.In this review,we will focus on overview of the latest research progressions of characteristic of EPC in the elderly with IHD,and on current studies of EPC-based angiogenesis therapies for providing theoretical basis in the promising clinical treatment.
