Current research progress on mouse model of frailty

VernacularTitle:老年衰弱小鼠模型的研究进展
Author: Qiukui HAO ; Ming YANG ; Biao DONG ; Birong DONG
Keywords: Frailty; Models,animal
From: Chinese Journal of Geriatrics 2017;36(9):1041-1043
CountryChina
Language:Chinese
Abstract: Frailty is a common state or syndrome with a decline in physiological reserves and an increase in an individual's vulnerability for stress in the elderly.Frailty can increase the risk of disability,falls,hospitalization,delirium and mortality.However,the intervention of frailty is under the scarcity and its effectiveness is not satisfied.We need to find new targets to treat frailty according to the pathophysiology of frailty.Human physiology is very similar to that of mouse,thus,mouse can be an ideal animal model of human disease.Mouse models can provide insight into pathogenesis of frailty by reducing the influence of genetic and environment factors and provide more basic data for further studies of frailty.At present,the research on a mouse model of frailty is still in its infancy and still needs further study.This review will summarize the related studies and propose some new ideas for future studies on mouse model of frailty.