Near-infrared light combined with tacrolimus ointment for the treatment of facial glucocorticoid-dependent dermatitis: a randomized controlled trial
10.3760/cma.j.issn.0412-4030.2017.09.013
- VernacularTitle:近红外光联合他克莫司软膏治疗面部激素依赖性皮炎的随机对照研究
- Author:
Jinning LIANG
;
Waishu JIN
;
Juan SHAO
;
Yan QU
;
Xiujuan XIA
- Keywords:
Dermatitis;
Face;
Spectroscopy,near-infrared;
Tacrolimus ointment;
Dermatitis,hormone-dependent
- From:
Chinese Journal of Dermatology
2017;50(9):670-672
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of near-infrared light combined with tacrolimus 0.1％ ointment in the treatment of facial glucocorticoid-dependent dermatitis.Methods A total of 68 patients with facial glucocorticoid-dependent dermatitis were enrolled from Department of Dermatology of Yantai Yuhuangding Hospital between December 2014 and December 2015,and randomly and equally divided into treatment group and combination group by a random number table.The treatment group was treated topically with tacrolimus ointment twice a day for 4 weeks.Besides the treatment with tacrolimus ointment,the combination group was irradiated with near-infrared light once a week for 4 sessions.After 4-week treatment,improvement in clinical manifestations such as itching and burning sensation was evaluated,so was the therapeutic effect.Results The combination group showed significantly higher response rate (85.3％ [29/34]) compared with the treatment group (61.8％ [21/34],x2 =4.84,P ＜ 0.05).Additionally,response rates for itching and burning sensation,erythema,scales and papules were all significantly higher in the combination group than in the treatment group (x2 =4.84,6.35,8.42 and 5.52,respectively,all P ＜ 0.05).Conclusion Near-infrared light combined with tacrolimus ointment is effective and safe for the treatment of facial glucocorticoid-dependent dermatitis.
