Clinical characteristics and prognosis for 126 patients with severe drug eruption
10.11817/j.issn.1672-7347.2017.08.013
- VernacularTitle:126例重症药疹住院患者的临床特征及预后
- Author:
Jie LI
;
Manyun MAO
;
Ni TANG
;
Rui ZHAI
;
Wu ZHU
;
Mei YI
;
Mingliang CHEN
- Keywords:
severe drug eruption;
clinical characteristics;
prognosis;
antimicrobials;
carbamazepine;
allopurinol
- From:
Journal of Central South University(Medical Sciences)
2017;42(8):953-957
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics of various types of severe drug eruption and common sensitized drugs,and to provide clinical references for reducing the incidence of severe drug eruption.Methods:The clinical data regarding 126 cases of severe drug eruption were analyzed retrospectively from June 2009 to May 2017 in Xiangya Hospital,Central South University.Results:In the 126 cases of severe drug eruption,the distribution of men and women ratio was 1∶1.38.The length of stay was (12.7±9.8) d.The most common type was Steven-Johnson syndrome;the most dangerous type was drug-induced bullosa epidermolysis,The most common sensitized drug category in these patients was antibiotics;the most common single sensitizing drug was carbamazepine,following by allopurinol.Conclusion:Severe drug eruption occurs mostly in young and middle-aged people.Steven-Johnson syndrome is the most common type;drug hypersensitive syndrome has the longest length of hospital course.Mortality rate of drug-induced bullosa epidermolysis is the highest.Timely stop using of allergens,early using glucocorticoids,and timely combination of non-glucocorticoids treatment (such as intravenous immunogloblin,plasma exchange and hemodialysis),can improve the efficacy and reduce the complications and mortality.
