Significance of p53 in cervical cancer and its influence on radiosensitivity
10.3760/cma.j.issn.1004-4221.2017.05.025
- VernacularTitle:p53基因在宫颈癌发病中的意义及对放射敏感性的影响
- Author:
Ping LI
;
Minbin CHEN
- Keywords:
p53 gene;
Cervical neoplasms;
Radiosensitivity;
Regulate
- From:
Chinese Journal of Radiation Oncology
2017;26(5):593-597
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is a major local treatment for cervical cancer.However, local uncontrollability due to radioresistance is still common.Therefore, the prediction of radiosensitivity is quite beneficial to develop an optimal treatment strategy for individual patients.Multiple factors could influence the radiosensitivity of cells, and p53 status is one of them.The upstream or downstream molecules of p53 could also be regulated to affect the radiosensitivity of cervical cancer.The aim of the review is to analyze the difference in p53 status between different types of cervical cancer and to discuss how p53 regulates the response to radiotherapy.
