Study of the default mode network alteration after subacute pontine infarction using rs-fMRI
10.3969/j.issn.1002-1671.2017.09.001
- VernacularTitle:亚急性期脑桥梗死脑默认网络的静息态fMRI研究
- Author:
Yongqiang ZHENG
;
Dongbai LIU
;
Xianping MENG
;
Bin LIU
;
Qitao JIANG
;
Xu WANG
;
Jinhua ZHANG
- Keywords:
resting-state functional magnetic resonance imaging;
isolated pontine infarction;
default mode network
- From:
Journal of Practical Radiology
2017;33(9):1329-1332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alteration and possible compensation mechanism of the default mode network (DMN) in patients with subacute pontine infarction.Methods Rs-fMRI data were collected from 23 patients with subacute pontine infarction and 23 normal controls.The data was analyzed with the functional connectivity (FC) method and compared between subacute pontine infarction patients and controls.All imaging was performed on a Philips Achieva 3.0T MRI scanner.Posterior cingulated cortox (PCC) was used as seed points to analyze the FC changes in the brain regions between the pontine infarction group and the controls.The discrepancies of experiment data between two groups were compared by using two-sample t-test analysis.Results The FC of the DMN showed a significant increase in the right postcentral gyrus, left medial prefrontal cortex and left precuneus compared with normal controls and a significant decrease in bilateral insula,posterior lobe of the left cerebellum,right parahippocampal gyrus and left inferior occipital gyrus.Conclusion The DMN altered in patients with subacute pontine infarction and the changes of the FC suggested the plasticity of cortical or compensation in the relevant brain areas.
