Vitamin D/vitamin D receptor, autophagy and inflammation relevant diseases
10.11817/j.issn.1672-7347.2017.08.017
- VernacularTitle:维生素D/维生素D受体、自噬与炎症相关疾病
- Author:
Aimei LI
;
Wei ZHANG
;
Hao ZHANG
;
Bin YI
- Keywords:
vitamin D/vitamin D receptor;
autophagy;
inflammation
- From:
Journal of Central South University(Medical Sciences)
2017;42(8):979-985
- CountryChina
- Language:Chinese
-
Abstract:
The biological effects mediated by vitamin D and vitamin D receptor (VDR) are involved in the regulation of multiple pathophysiologic processes,including calcium phosphorus metabolism,immune regulation,anti-inflammation,anti-infection and cancer prevention,etc.Autophagy is a eukaryotic cell lysosome-mediated catabolic pathway,which is classified into 3 different types:macroautophagy,microautophagy,and chaperone-mediated autophagy.Since autophagy is vital to maintain energy and metabolism in cells,autophagy dysfunction is closely associated with various pathological processes such as inflammation,infection and tumor.Studies have shown that vitamin D/VDR can affect the different stages of autophagy and regulate inflammation in autophagy.Moreover,vitamin D/VDR and autophagy play an important role in autoimmune disease,diabetes,cardiovascular disease,cancer and other inflammatory diseases.
