Correlation between ABCB1 Polymorphisms and Synergistic Effects of Wuzhi Capsules on Tacrolimus
10.3969/j.issn.1008-049X.2017.09.004
- VernacularTitle:ABCB1基因多态性与五酯胶囊对他克莫司增效作用的相关性研究
- Author:
Yan YANG
;
Huawen XIN
- Keywords:
ABCB1;
Genic polymorphism;
Wuzhi capsules;
Tacrolimus;
Renal transplantation
- From:
China Pharmacist
2017;20(9):1529-1532,1542
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of ABCB1 polymorphisms and the synergistic effect of Wuzhi capsules on ta-crolimus. Methods:The ABCB11236C>T(rs1128503), ABCB12677G>T/A(rs2032582) and ABCB13435C>T(rs1045642) genotypes were determined by restriction fragment length polymorphism ( RFLP) analysis. The whole blood levels of tacrolimus in renal transplant recipients were measured by chemiluminescent microparticle immunoassay. Analysis of covariance ( ANCOVA) was per-formed to determine the difference of tacrolimus C0/D among the various groups. Results: Whether co-administeration of Wuzhi cap-sules and tacrolimus or not, tacrolimus C0/D of ABCB11236C>T, ABCB12677G>T/A and ABCB13435C>T genotype and haplo-type was without significant difference. Conclusion:When combined with Wuzhi capsules, ABCB11236C>T, ABCB12677G>T/A and ABCB13435C>T mutation is not associated with tacrolimus C0/D.
