Role of Emotional Stimulation and Endogenous Hydrogen Sulfide in the Development of Atherosclerosis
10.3969/j.issn.1008-049X.2017.09.006
- VernacularTitle:情志刺激和内源性硫化氢与动脉粥样硬化发病的相关实验研究
- Author:
Hua FAN
;
Xiuying WANG
;
Zhilong ZHAO
;
Peng LIN
;
Dan SUN
;
Lina WANG
;
Qiang KANG
;
Jiayi CHENG
;
Yajun LI
- Keywords:
Emotional stimulation;
Atherosclerosis;
Qi-stagnation and blood-stasis atherosclerosis;
Hydrogen sulfide
- From:
China Pharmacist
2017;20(9):1538-1542
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of emotional stimulation on the formation process of atherosclerosis ( AS) ,and explain the role of hydrogen sulfide ( H2 S) in atherosclerotic lesions. Methods:Twenty-four Sprague-Dawley rats were randomly divided into AS group, qi-stagnation and blood-stasis AS group and the control group. The AS group was fed with special diets, the qi-stagnation and blood-stasis AS group was fed with special diets and emotional stimulation, and the control group was fed with normal diets. During the experiment, the indicators including the characterization score, H2 S content, four items of the natural bleeding and blood coagula-tion, tissue blood flow and blood lipid were respectively detected in the 4 th, 8 th and 12 th week. Results:Compared with those in the AS group, since the 4 th week, the rats in qi-stagnation and blood-stasis AS group were with significantly decreased activity, slow re-sponse, lackluster fur and dark purple tongue (P<0. 01);the level of plasma lipid increased significantly, and increased further with time extension(P<0. 05 or P<0. 01);since the 8 th week, APTT and FIB changed significantly (P<0. 05),the blood flow to skin, liver and kidney decreased significantly (P<0. 05);the content of H2S was significantly higher in the 12 th week (P<0. 01). Con-clusion:Emotional stimulation promotes the formation of AS model,and the gas molecule system of H2 S plays a regulatory role in the qi-stagnation and blood-stasis AS animal model.
