Research Progress in Anti-radiation Drug:Ex-RAD
10.3969/j.issn.1008-049X.2017.09.030
- VernacularTitle:抗辐射药Ex-RAD的研究进展
- Author:
Juan JING
;
Libin WANG
;
Tian FENG
;
Shufeng ZHANG
;
Haiying HUANG
;
Chang LIU
;
Xiang LI
;
Yong HAO
- Keywords:
Ex-RAD;
Anti-ionizing radiation;
Content determination;
Pharmacological effects
- From:
China Pharmacist
2017;20(9):1631-1633
- CountryChina
- Language:Chinese
-
Abstract:
Ex-RAD (ON01210) is a novel and efficient anti-radiation drug with low toxicity developed by US army and Onconova Pharmaceuticals in recent years. The significant survival advantage and low toxicity of Ex-RAD have contributed to the approval by the FDA as an investigational new drug in December 2008. Meanwhile, the drug is currently in phase I clinical trials in humans. In this paper, the chemical structure, synthesis route, detection method and pharmacological action of Ex-RAD were reviewed, and the appli-cation prospect of Ex-RAD was also explored.
