MRI manifestations of central nervous system involvement in neonatal pigmentary incontinence

VernacularTitle:新生儿色素失禁症中枢神经系统受累的MRI表现
Author: Mingxia HUANG ; Dong WANG ; Chao CHEN ; Hua CHEN ; Zengjun ZHANG
Keywords: newborn infant; incontinentia pigmenti; central nervous system; magnetic resonance imaging
From: Journal of Practical Radiology 2017;33(9):1424-1426
CountryChina
Language:Chinese
Abstract: Objective To explore MRI features of incontinentia pigmenti(IP) in central nervous system (CNS) in newborn infants.Methods MRI and clinical data of 17 cases of IP which confirmed by clinic,skin biopsy or NEMO gene test were analyzed retrospectively.Results There were 17 cases with IP in this study.MRI abnormalities were found in 12 cases, among which 3 cases showed high signal intensity on T2WI and a reduced signal intensity on T1WI,and 9 cases showed normal signal intensity on traditional MRI.Multiple areas of restricted diffusion were found in 12 cases which showed asymmetric high signal intensity in bilateral cerebral cortex and subcortical area, basal ganglia,centrum semiovale and periventricular area on DWI.In addition,basal ganglia was involved in 4 cases,corpus callosum was involved in 5 cases, and thalamus was involved in 2 cases.Conclusion MRI of IP in CNS shows certain specific characteristics.DWI plays an important role in the early detection and prognosis of the disease.