Effects of Tiaoxin Formula on Spatial Learning and Memory Ability and LTP in Hippocampus of APP/PS1 Double Transgenic Mice with Alzheimer Disease
10.3969/j.issn.1005-5304.2017.10.010
- VernacularTitle:调心方对APP/PS1双转基因AD小鼠空间学习记忆能力和海马突触传递长时程增强的影响
- Author:
Xiaowen WANG
;
Haiyan DENG
;
Jian WANG
;
Ying XU
- Keywords:
Tiaoxin Formula;
Morris water maze;
LTP in hippocampus;
Alzheimer disease;
learning and memory ability;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2017;24(10):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Tiaoxin Formula on spatial learning and memory ability and long-term potentation (LTP) in the hippocampus of APP/PS1 transgenic mice with Alzheimer disease; To discuss its mechanism of action. Methods Totally 54 three-month-old APP/PS1 transgenic mice were randomly divided into model control group, Tiaoxin Formula group and positive control group, with 18 mice in each group. Another 18 three-month-old C57BL/6J wild mice were chosen as normal control group. All administration groups receive relevant medicine. 12 weeks later, Morris water maze test was used to test behavior and in vitro electrophysiology record. Results The Morris water maze test showed that in place navigation test, compared with the model control group, escape latency time in Tiaoxin Formula group was significantly reduced (P<0.01). In the space experiments, compared with the model control group, the number of crossing the platform quadrant and the time staying at the platform quadrant in Tiaoxin Formula group were significantly increased (P<0.05, P<0.01). In vitro hippocampal electrophysiological induction, compared with the model control group, fEPSP slope in the hippocampus in Tiaoxin Formula group were significantly increased (P<0.01), the PPF had no significant difference (P>0.05). Conclusion Tiaoxin Formula can improve the spatial learning and memory ability and LTP of APP/PS1 transgenic mice with Alzheimer disease, thus can realize cognitive protection effects.
