Alkali Therapy Attenuates the Progression of Kidney Injury via Na/H Exchanger Inhibition in 5/6 Nephrectomized Rats.
10.3346/jkms.2014.29.5.691
- Author:
Sejoong KIM
1
;
Jeonghwan LEE
;
Nam Ju HEO
;
Jae Wook LEE
;
Jin Suk HAN
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. jshan@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Sodium Bicarbonate;
Acidosis;
Kidney Failure, Chronic
- MeSH:
Acidosis/*drug therapy;
Alkalies/*therapeutic use;
Animals;
Caseins/administration & dosage;
Disease Progression;
Glomerular Filtration Rate/drug effects;
Glomerulosclerosis, Focal Segmental/drug therapy;
Kidney/injuries;
Male;
Nephrectomy;
Nephritis, Interstitial/drug therapy;
Rats;
Rats, Sprague-Dawley;
Renal Insufficiency/*drug therapy;
Sodium Bicarbonate/*therapeutic use;
Sodium Chloride/administration & dosage;
Sodium-Hydrogen Antiporter/*antagonists & inhibitors
- From:Journal of Korean Medical Science
2014;29(5):691-698
- CountryRepublic of Korea
- Language:English
-
Abstract:
Metabolic acidosis is a cause of renal disease progression, and alkali therapy ameliorates its progression. However, there are few reports on the role of renal acid-base transporters during alkali therapy. We evaluated the effect of sodium bicarbonate therapy and the role of acid-base transporters on renal disease progression in rats with a remnant kidney. Sprague-Dawley rats consumed dietary sodium bicarbonate (NaHCO3) or sodium chloride (NaCl) with 20% casein after a 5/6 nephrectomy. After being provided with a casein diet, the NaHCO3-treated group had higher levels of serum bicarbonate than the control group. At week 4, the glomerular filtration rate in the NaHCO3 group was higher than that in the NaCl group, and the difference became prominent at week 10. The glomerulosclerosis and tubulointerstitial damage indices in the NaHCO3 group were less severe compared with controls at week 4 and 10. The expression of the Na/H exchanger (NHE) was decreased, and apical reactivity was decreased in the NaHCO3 group, compared with the NaCl group. Endothelin-1 levels in the kidney were also decreased in the NaHCO3 group. Dietary sodium bicarbonate has the effects of ameliorating renal disease progression, which may be related to the altered expression of NHE in the remaining kidney.
