Diterpenoid Alkaloids in the Roots of Aconitum Bulleyanum Diels
10.3969/j.issn.1008-049X.2017.09.003
- VernacularTitle:滇西乌头二萜生物碱成分研究
- Author:
Xiaoyan DUAN
;
Yong SHEN
- Keywords:
Ranunculaceae;
Aconitum bulleyanum;
Diterpenoid alkaloids
- From:
China Pharmacist
2017;20(9):1525-1528
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents in the roots of Aconitum bulleyanum Diels. Methods: The air-dried roots of A. bulleyanum were powdered and extracted by methanol with percolation. After removing the solvent under reduced pressure, the crude extract was dissolved in 1. 5％ HCl solution, and then basified to pH 9 by NaOH (5％) and extracted by ethyl acetate to ob-tain crude alkaloidal extract after ethyl acetate removal. The alkaloidal extract was isolated and purified by column chromatography, and their structures were identified based on spectral analysis ( 1 H-NMR, 13 C-NMR, MS) . Results:Totally 12 diterpenoid alkaloids were isolated from A. bulleyanum and characterized as foresaconitine (1), crassicauline A (2), chasmanine (3), talatisamine (4), 14-debenzoyl-franchetine (5), pengshenine A (6), crassicautine (7), yunaconitine (8), franchetine (9), liljestrandisine (10), transconitine B (11) and pseudoaconine (12). Conclusion:Compounds 3-7, 10-12 are isolated from this plant for the first time.
