Literature Analysis on Drug-induced Second Thrombocytosis

VernacularTitle:药物致继发性血小板增多症文献分析
Author: Shenjue CHEN ; Xin LI ; Lihua LIU ; Xin HE ; Hongling MA ; Mingxiang ZHANG
Keywords: Adverse drug reactions; Second thrombocytosis; Literature analysis
From: China Pharmacist 2017;20(9):1633-1635
CountryChina
Language:Chinese
Abstract: Objective:To explore the clinical characteristics, mechanism and countermeasures of drug-induced second thrombocy-tosis ( ST) in order to ensure safe medication. Methods:Drug-induced ST published during 1996 and 2016 in domestic and overseas medical journals was collected and statistically analyzed in respects of age, gender, kind and distribution of drug-induced ST, treatment and outcome of ST. Results:Totally 198 cases were collected, which involved 30 different drugs of eight types mainly including antitu-mor drugs, blood system drugs and antibiotics. Among the patients, 112 ones (56. 6％) were male and the other 86 ones (43. 4％) were female. Totally 14 patients had embolization with the overall incidence of 7. 0％. Conclusion:Without timely and favorable treat-ment, drug-induced ST may lead to thrombosis. To ensure the safety of medication, platelet level should be monitored regularly during medication.