Diagnosis and surgical treatment of pancreatic neuroendocrine neoplasms
10.3760/cma.j.issn.1007-8118.2017.08.001
- VernacularTitle:胰腺神经内分泌肿瘤的诊断与外科治疗
- Author:
Xudong ZHAO
;
Xiaodong TIAN
;
Yinmo YANG
- Keywords:
Pancreatic neuroendocrine neoplasms;
Risk factors;
Prognosis;
Diagnosis;
Surgical treatment
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(8):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnosis,treatment and prognostic factors of pancreatic neuroendocrine neoplasms (pNENs).Methods The clinical,pathological and follow-up data of 44 patients with pNENs treated at the Peking University First Hospital from Jan.2007 to Dec.2016 were retrospectively studied.Survival analysis was performed with the Kaplan-Meier method.Results There were 21 male and 23 female patients.The mean age was (54.8 ± 14.0) years.25 patients had non-functional,while 19 had functional pNENs.Curative resection was performed in 40 patients.Neural invasion and intravascular cancer emboli were found in 7 and 5 patients,respectively.The pathologic data showed that the number of patients with G1,G2,G3 were 23 (52.3 ％),15 (34.1％),6 (13.6％),respectively.The number of patients with stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ were 23 (52.3 ％),16 (36.4％),2 (4.5 ％) and 3 (6.8 ％),respectively.The predictive factors on prognosis included curative resection or not,WHO grade,TNM staging,lymph node metastasis and distant metastasis (P ＜ 0.05).Conclusions Curative surgical resection is the first choice of treatment for pNENs.WHO grade,TNM staging,lymph node metastasis and distant metastasis were significantly related to the prognosis of pNENs.
