Osteopontin Promoter Polymorphism at Locus-156 is Associated with HCC in Patients with HBV Infection in Chinese Population
- VernacularTitle:OPN基因启动区-156delG多态性与中国HBV相关肝细胞癌的易感性
- Author:
Hong SHI
;
Yuankai WU
;
Guoli LIN
;
Xiangyong LI
- Keywords:
osteopontin;
polymorphism;
hepatocellular carcinoma;
Hepatitis B,chronic
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(5):717-721
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the association between the polymorphisms in the promoter region of Osteopontin(OPN)with hepatitis B virus(HBV)-related HCC.[Methods]A total of 225 cases diagnosed with hepatitis B virus(HBV)-related HCC and 200 age-matched patients with HBV infection without HCC were collected. Three polymorphisms(-156delG/G,-443T/C and-616T/G)in the Osteopontin promoter were genotyped using direct sequencing.[Results]The frequency of-156delG/delG genotype in the HCC group was higher than that of in the control group (P = 0.003). There was a significantly increased frequency of the allele-156delG(P<0.001)in HCC patients. Logistic regression analysis was performed to show an increase HCC risk associated with the delG variant genotype(OR1.64;95%CI 1.25~2.16). There were no differences between the groups in the genotype distributions and allele frequencies of SNP-443T/C and-616T/G.[Conclusion]Our findings suggest that allele-156delG in the Osteopontin promoter may be a marker for risk of HCC with HBV infection in Chinese Han population.
