Effect of Donepezil on Dysgnosia in Patients with General Paralysis of the Insane
- VernacularTitle:多奈哌齐辅助治疗对轻-中度麻痹性痴呆病人的疗效
- Author:
Shuqiong LIU
;
Lianhong YANG
;
Yanran LIANG
;
Chao CHEN
- Keywords:
general paralysis of the insane;
anti-syphilis treatment;
donepezil
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(5):722-726
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the effect of Donepezil on dysgnosia in patients with mild-moderate general paralysis of the insane(GPI).[Methods]Forty-seven patients with GPI were assigned into study group(n=24)or control group(n=23). All these patients were treated with a large dose of penicillin for 2 weeks and then with Benzathine for 3 weeks. And the Donepezil admin-istered to patients in study group.The mini-mental state examination(MMSE)and the clinical dementia rating(CDR)were scored as the measurement of efficiency.[Result]The scores of the MMSE and CDR were not statistically different between the two groups at baseline and 4 weeks after treatment,and both were increased 12 weeks after treatment(P<0.05),especially in study group as com-pared with those in control group(P < 0.05).[Conclusion]Donepezil as an adjunctive therapy may be effective for dysgnosia in patients with mild-moderate GPI. Donepezil is also safe and well tolerated.
