Mechanism of Clinical Cross Allergy Reaction of β-lactam Antibiotics and Introduction of Related Treat-ment Processes in USA
10.6039/j.issn.1001-0408.2017.26.32
- VernacularTitle:β-内酰胺类抗菌药物临床交叉过敏反应的发生机制及美国相关处理流程介绍
- Author:
Ping LI
;
Shuhong BU
;
Jia ZHOU
;
Huijuan YAO
;
Xinzhu LIU
- Keywords:
β-lactam antibiotics;
Cephalosporin;
Penicillin;
Allergy history;
Cross allergy
- From:
China Pharmacy
2017;28(26):3711-3715
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the mechanism of cross allergy reaction during the application of β-lactam antibiotics, and to provide reference for rational drug use in clinic. METHODS:Based on study experience of author in UIC and its affiliated hospital during advanced study,according to the experience of drug use safety management in patients allergic to β-lactam antibiot-ics from Rush University Medical Center,the mechanism of cross allergy reaction during the application of β-lactam antibiotics was summarized,and the disposal procedure for patients allergic to β-lactam antibiotics in the Affiliated Hospital of UIC was intro-duced. RESULTS:The principal reason for cross allergy reaction induced by β-lactam antibiotics were same or similar side chains between drugs. Cross allergy reaction occurred when IgE recognized these side chains. The disposal procedure for patients allergic to β-lactam antibiotics in the Affiliated Hospital of UIC included that the indication of β-lactam use was evaluated;standard penicil-lin skin testing according to evaluation results,anti-infection treatment by Grade challenge β-lactam antibiotics and course and rap-id drug tolerance induction. CONCLUSIONS:The disposal method for patients allergic to β-lactam antibiotics in the Affiliated Hos-pital of UIC can provide new thought for domestic clinical pharmacists in rational drug use among the patiens with reported aller-gies to special group as pregnant women,children.
