Diagnosis of brain tumor with multi-modality imaging of 11C-MET PET combined with functional MRI
10.3760/cma.j.issn.2095-2848.2017.09.002
- VernacularTitle:11C-MET PET结合功能MRI多模态显像诊断脑肿瘤的价值
- Author:
Haodan DANG
;
Changbin LIU
;
Ruimin WANG
;
Jiajin LIU
;
Zhiwei GUAN
;
Liping FU
;
Can LI
;
Jinming ZHANG
;
Jiahe TIAN
;
Baixuan XU
- Keywords:
Brain neoplasms;
Positron-emission tomography;
Magnetic resonance imaging;
Methionine
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(9):527-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic efficiency of the parameters obtained from PET/MR in brain tumors.Methods In this prospective study,28 patients (21 males,7 females,age range: 6-82 years) with clinical suspicion of brain tumor from November 2012 to September 2015 underwent PET/MR multi-modality imaging.The examination of PET/MR included 11C-MET PET and multiple MR sequences.The qualities of images were estimated firstly.The ROC curve and the accuracy of SUVmax,ADCmean,rCBF and NAA/(Cho+Cre) ratio were calculated.The pathology or final clinical diagnosis was taken as the standard.The diagnostic efficiency of the multi-modality imaging was determined based on the cutoff values of the four parameters.Two-sample t test was used to analyze the differences of parameters between glioma group and inflammatory group.Results SUVmax,ADCmean,rCBF and NAA/(Cho+Cre) ratio were validated to be effective parameters in diagnosing brain tumors with the diagnostic accuracy of 89.3％(25/28),82.1％(23/28),78.6％(22/28) and 75.0％(21/28),respectively.The SUVmax exhibited the highest diagnostic accuracy,while the diagnostic efficiency of the combination of four parameters was superior to the separate parameter.The values of SUVmax,rCBF and NAA/(Cho+Cre) ratio were significantly different between glioma group(n=10) and inflammatory group(n=11;t values:-2.31,-3.11,-2.77,all P<0.05).Conclusions PET/MR can provide a one-stop examination with multi-modality imaging of brain.The obtained parameters SUVmax,ADCmean,rCBF and NAA/(Cho+Cre) ratio,especially their combination,have effective diagnostic values on brain tumor.
