Gender differences of brain metabolic networks: a 18F-FDG PET study
10.3760/cma.j.issn.2095-2848.2017.09.005
- VernacularTitle:18F-FDG PET脑代谢网络的性别差异
- Author:
Lei FANG
;
Jianping AN
;
Junfeng MAO
;
Xuejiao CHEN
;
Yuanwei XIE
;
Hui ZHAO
;
Wansheng LIANG
;
Changshuai YAO
- Keywords:
Adult;
Brain;
Metabolic network and pathways;
Sex factors;
Positron-emission tomography;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(9):544-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the gender differences of glucose metabolic network in brains of healthy adults at resting state by 18F-FDG PET.Methods A total of 204 dextromanual,healthy individuals (104 males,average age:(53.45±11.51) years;100 females,average age:(54.11±12.09) years) were enrolled from June 2011 to June 2016 to construct brain metabolic networks.The nodal and global parameters,including clustering coefficient (Cp),characteristic path length (Lp) and betweenness centrality (Cb),were analyzed by graph theory.Permutation test with 1 000 repetitions was used.Results The brain metabolic networks derived from 18F-FDG PET data were with small-world properties in both male group and female group.Compared with Cb in females,Cb in males was significantly reduced in left postcentral gyrus,right angular gyrus and left temporal pole/middle temporal gyrus (permutation test,all P<0.05);and it was increased in left amygdala,left precuneus,right temporal pole/middle temporal gyrus and left inferior temporal gyrus (permutation test,all P<0.05).Comparing with the females,the male group had higher Cp and longer absolute Lp but without significant difference (permutation test,all P>0.05).Conclusions There are gender-related differences of topological structure in whole-brain metabolic networks.Gender should be considered as a covariate while designing experiments,accounting for cerebral metabolic data from normal control and experimental patients as well as making clinical decisions.
