Application Research of T2*Mapping in Evaluating Inflammatory Activity in Crohn Disease
- VernacularTitle:T2*mapping评估克罗恩病炎症活动性的应用研究
- Author:
Siyun HUANG
;
Xuehua LI
;
Zhuangnian FANG
;
Mengchen ZHANG
;
Shiting FENG
;
Canhui SUN
;
Ziping LI
;
Shaochun LIN
- Keywords:
T2* mapping;
MR enterography;
Crohn disease;
MaRIA
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(5):759-764,773
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the efficacy of T2* mapping for evaluating inflammatory activity in the patients with Crohn disease(CD).[Methods]A total of 98 CD patients underwent MR enterographywith T2*WI. T2* values were measured by put-ting regions of interest on the thickening bowel wall on T2*mapping. The activity of bowel segment was scored by magnetic resonance index of activity(MaRIA),to analyze the relationship between T2*values with CD activity.[Results]A total of 160 bowel segments were evaluated and includedinactive(MaRIA<7,n=26),mild(7≤MaRIA<11,n=23),and moderately-severe(MaRIA≥11, n = 111)active lesions. The differences in T2* values amongthese three groups were significant(all P < 0.05). T2* values of 160 bowel segments correlatedclosely withMaRIA(r=0.743,P<0.05). High accuracy of T2*values was shown for differentiating inac-tive from active CD(AUC=0.877)anddifferentiating inactive-mild from moderate-severe CD(AUC=0.848). The threshold T2*value of 20 ms allowed differentiation of mild from moderate-severe CD with74.5%sensitivity and 84%specificity.[Conclusions]T2*values, as thequantitative indexof T2*mapping,correlate well with CD activity and showsatisfiedefficacy for diagnosing inflammatoryactivity.
