Clinical Observation of Breviscapine Combined with Vinpocetine in the Treatment of Acute Cerebral In-farction
10.6039/j.issn.1001-0408.2017.26.22
- VernacularTitle:灯盏花素联合长春西汀治疗急性脑梗死的临床观察
- Author:
Shiting FENG
;
Li LI
;
Yun LIN
- Keywords:
Breviscapine;
Vinpocetine;
Acute cerebral infarction;
Copeptin;
NT-proBNP;
Ischemia modified albumin
- From:
China Pharmacy
2017;28(26):3678-3681
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate clinical efficacy and safety of breviscapine combined with vinpocetine in the treatment of acute cerebral infraction. METHODS:A total of 80 patients with acute cerebral infraction were selected from our hospital during Jan. 2014-Dec. 2015,and then divided into observation group and control group according to random number table,with 40 cases in each group. Control group was given Vinpocetine injection 20 mL+0.9％ Sodium chloride injection 250 mL,ivgtt,qd. Observa-tion group was additionally given Breviscapine injection 20 mL+5％ Glucose injection 250 mL,ivgtt,qd,at intervals of 2-3 h on the basis of control group. Both groups were treated for 2 weeks. Clinical efficacies as well as serum copeptin,NT-proBNP,albu-min cobalt binding(ACB)value,European stroke scale(ESS)and functional independence measurement(FIM)score before and after treatment were observed in 2 groups,and the occurrence of ADR was recorded. RESULTS:Total response rate of observation group(90.0％)was significantly higher than that of control group(67.5％),with statistical significance(P<0.05). Before treat-ment,there was no statistical significance in serum peptide,NT-proBNP,ACB value,ESS or FIM score between 2 groups (P>0.05). After treatment,serum copeptin and NT-proBNP levels of 2 groups were decreased significantly,while ACB value,ESS and FIM score were increased significantly;the improvement of observation group was significantly better than that of control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Breviscapine combined with vinpocetine can improve neurological function of acute cerebral infraction patients and show good therapeutic efficacy with good safety.
