Statistical parametric mapping-based interhemispheric asymmetry analysis of 18F-FDG PET brain imaging in localization of unilateral temporal lobe epileptic foci
10.3760/cma.j.issn.2095-2848.2017.09.004
- VernacularTitle:基于统计参数图的脑内不对称分析法在18F-FDG PET代谢显像对单侧颞叶癫(间)定侧定位诊断上的应用
- Author:
Xiaoyang WANG
;
Chunlei ZHAO
;
Hui LI
;
Liyuan FU
;
Dandan LIN
;
Ziqian CHEN
- Keywords:
Epilepsy,temporal lobe;
Diagnosis;
Positron-emission tomography;
Tomography,X-ray computed;
Image processing,computer-assisted;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(9):538-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of the SPM-based interhemispheric asymmetry analysis (SIAA) of 18F-FDG PET brain imaging in localization of temporal lobe epileptic foci.Methods A total of 73 patients (42 males,31 females,average age: (27.10±9.78) years) diagnosed as temporal lobe epilepsy (TLE) and 30 healthy volunteers (17 males,13 females,average age: (33.79±5.46) years) from March 2012 to July 2015 were enrolled in this retrospective study.18F-FDG PET brain imaging was performed on all subjects to localize temporal lobe epileptic foci.The results of 18F-FDG-PET were analyzed by SIAA,visual analysis and asymmetry index (AI) analysis.The accuracy of the three methods was evaluated according to the postoperative pathological results and curative effect.χ2 test and partition of χ2 test were used to analyze the data.Results The accuracies of localization with SIAA,visual analysis and AI analysis were 87.67％(64/73),75.34％(55/73) and 69.86％(51/73),respectively (χ2=6.993,P<0.05).The accuracy of SIAA was higher than that of visual analysis and AI analysis (χ2 values: 5.818 and 8.481,both P<0.017),while there was no significant difference between AI analysis and visual analysis (χ2=0.500,P>0.017).Conclusion The SIAA of 18F-FDG PET brain imaging may be a more objective and accurate method in localization of TLE foci.
