Relationship between the initial change of Tg and outcome in differentiated thyroid carcinoma patients with pulmonary metastases after 131I treatment
10.3760/cma.j.issn.2095-2848.2017.09.007
- VernacularTitle:分化型甲状腺癌肺转移131I治疗后早期Tg变化与远期临床转归的关系
- Author:
Chen WANG
;
Teng ZHAO
;
Jiao LI
;
Wen GAO
;
Yansong LIN
- Keywords:
Thyroid neoplasms;
Neoplasm metastasis;
Lung;
Radiotherapy;
Iodine radioisotopes;
Treatment outcome;
Thyroglobulin
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(9):555-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the initial change of Tg and clinical outcome in DTC patients with pulmonary metastases after 131I treatment.Methods A total of 47 DTC patients (13 males,34 females;average age (41.6±16.3) years) with pulmonary metastases from January 2008 to June 2014 were retrospectively analyzed.Patients were divided into 3 groups according to the variation of Tg: G1 with a declined (more than 50％) Tg;G2 with a declined (less than 50％) Tg or an increased (less than 10％) Tg;G3 with an increased (more than 10％) Tg.The median follow-up time was 1 501 d.Clinical outcomes were divided into remission,stable disease and progressive disease according to the serum test and imaging results.Data analysis was performed by χ2 test and Fisher exact test.Results The percentage of G1,G2,G3 patients was 44.7％(21/47),40.4％(19/47),and 14.9％(7/47) respectively.Results of follow-up showed 19.0％(4/21) patients achieved remission and 81.0％(17/21) with stable disease in G1.There were 2/19 with remission,12/19 with stable disease and 5/19 with progression disease in G2.All patients (7/7) had progressive disease in G3.The clinical outcome was related to the variation of Tg after 131I treatment (Fisher exact test,P<0.01).Conclusions Initial Tg after 131I treatment could be a predictor to the outcome of patients.The increased Tg level indicates a high possibility of 131I refractory disease.
