Efficiency of glucocorticoid treatment in IgA nephropathy with massive proteinuria
10.3760/cma.j.issn.1001-7097.2017.08.001
- VernacularTitle:糖皮质激素治疗表现为大量蛋白尿的IgA肾病患者的疗效及预后分析
- Author:
Zhenjie CHEN
;
Hang LI
;
Jianfang CAI
;
Yubing WEN
;
Chao LI
;
Peimei ZOU
;
Xin ZHANG
;
Mingxi LI
;
Limeng CHEN
;
Xuemei LI
;
Xuewang LI
- Keywords:
Glomerular nephritis,IgA;
Proteinuria;
Nephrotic syndrome;
Glucocorticoids
- From:
Chinese Journal of Nephrology
2017;33(8):561-566
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological characteristics of IgAN patients with massive proteinuria,as well as their treatment response to glucocorticoids and long-term prognosis.Methods Clinical and pathological parameters were collected in patients diagnosed with IgA nephropathy in our hospital from Jan 2003 to Oct 2015.Patients were followed up for at least six months under the treatment with full dosage of glucocorticoids.Responses of patients with and without nephrotic syndrome were compared.Results A total of 156 patients were enrolled for the analysis (86 patients in the nephropathic proteinuria group,and 70 patients in the nephrotic syndrome group).Patients presented with nephrotic syndrome showed higher proportion of IgM deposition in renal slides.There exited no difference in treatment response to glucocorticoids between the two groups.Patients with full or partial remission showed a better prognosis by Kaplan-Meier analysis than no remission group (P ＜ 0.001).The ratio of segmental sclerosis was negatively correlated with treatment response to glucocorticoids by multiple linear regression (3 value=-0.330,P ＜ 0.001).Multivariate Cox regression model showed that glomerular density (HR=0.45,P=0.02) and eGFR (HR=0.95,P=0.001)were independent influential factors for renal survival.Conclusions Patients presented with nephrotic syndrome show higher proportion of IgM deposition in renal slides.Patients in remission after treatment with 6-month glucocorticoids present a better prognosis than no remission patients,and glomerular density as well as eGFR are independent influential factors for renal survival.
