Prevention Effects of Different Treatment Courses of Antibiotics in Fracture Patients during Perioperative Period of Incision Internal Fixtion: A Meta-Analysis
10.6039/j.issn.1001-0408.2017.24.22
- VernacularTitle:骨折患者切开内固定术围术期使用不同疗程抗菌药物预防感染的Meta分析
- Author:
Dong LIU
;
Jin ZHANG
;
Ziyun LIU
;
Xiaoyu ZHANG
;
Fengli JIANG
;
Yiping WU
- Keywords:
Closed fracture;
Prophylactic application of antibiotics;
Surgical site infection;
Meta-analysis;
Therapeutic efficacy
- From:
China Pharmacy
2017;28(24):3390-3394
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate therapeutic efficacies of perioperative application of single-dose and multipie-dose of antibiotics for preventing surgical site infection after closed fractures patients receive incision and internal fixation,and to provide evidence-based reference.METHODS:Retrieved from PubMed,EMBase,CBM,Cochrane Library,CBM,CJFD,VIP and Wanfang database,RCTs about perioperative application of single-dose (trial group) and multiple-dose (control group) of antibiotics for preventing surgical site infection after closed fractures patients receive incision and internal fixation were collected.Meta-analysis was performed using Rev Man 5.3 statistical software after literature screening,data extraction and quality evaluation by improved Jadad.RESULTS:Finally 8 clinical studies were included,involving 3 457 patients.The results of Meta-analysis showed that there was no statistical significance in the rate of surgical site infection [OR=1.02,95％ CI(0.63,1.66),P=0.94)].Cefazolin stadies were included in subgroup analysis according to drug use,and results of Meta-analysis showed that there was no statistical significance in the rate of surgical site infection[OR=1.33,95％CI(0.55,3.20),P=0.52].CONCLUSIONS:Prophylactic application of single-dose of antibiotics is recommended for preventing surgical site infection after closed fractures patients receive incision and internal fixation.
