IgG4-Related Disease with lymphadenopathy Presenting as a Cervical lymph node enlargement.
10.7180/kmj.2017.32.2.233
- Author:
Yeon Seok CHOI
1
;
SungMin KIM
;
Jang Sihn SOHN
;
JiYong HWANG
;
TaeSoo CHANG
;
Do Yeon CHO
Author Information
1. Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, Korea. dycho@kyuh.ac.kr
- Publication Type:Case Report
- Keywords:
Immunoglobulin G4;
Lymphadeopathy
- MeSH:
Aged;
Biopsy;
Diagnosis, Differential;
Humans;
Immunoglobulin G;
Immunoglobulins;
Lymph Nodes*;
Lymphatic Diseases*;
Neck;
Pancreatitis;
Plasma Cells
- From:Kosin Medical Journal
2017;32(2):233-239
- CountryRepublic of Korea
- Language:English
-
Abstract:
During the course of evaluation and management of neck masses, consideration for Immunoglobulin G4-related disease (IgG4-RD) should be given. IgG4-RD is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis. A previously healthy 72-year-old man was referred to our clinic with a 2-month history of left cervical lymph node enlargement without systemic manifestations . A cervical lymph node biopsy was planned because of elevated serum IgG4 levels. Pathological findings showed prominent infiltration of IgG4-postive plasma cells in the lymph node. After steroid therapy, a computed tomography scan revealed a decrease in the cervical lymph node size. This case illustrates the importance of including IgG4-RD in the differential diagnosis of a cervical lymph node enlargement.
