Methodology Exploration for Multi-component Chinese Medicine Based on Protein Signal Transduction Network
10.11842/wst.2017.05.001
- VernacularTitle:基于蛋白信号转导网络的组分中药研究方法学
- Author:
Wenxing CHEN
;
Xu WANG
;
Aiyun WANG
;
Yin LU
- Keywords:
Protein signal transduction network;
principle of Chinese medicine prescription;
multi-component Chinese medicine;
methodology
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(5):725-729
- CountryChina
- Language:Chinese
-
Abstract:
Multi-component Chinese medicine has been considered an important developmental direction for traditional Chinese medicine (TCM) formula.Nowadays,it is unfit to target a molecule for preventing or curing a disease because it resulted from multiple of factors and resulted in many indications.Thus,the idea focusing on the multiple targets for therapy is increasingly accepted by physicians and scientists.Here,we conceived a new simplified method for screening the active multi-component Chinese medicine based on the complexity of Chinese medicine,the multi-target property of protein signal transduction and the principle of Chinese medicine prescription.Combined with the traditional knowledge on tumor and latest antitumor research results of Chinese medicine and its compounds,the method was concretely illustrated.It helps us to transform the herbal compounds to new complex drugs targeting multiple signaling.
