Expression profile of long non-coding RNA in non-alcoholic fatty liver disease
10.11817/j.issn.1672-7347.2017.07.001
- VernacularTitle:非酒精性脂肪肝病中长链非编码RNA的表达谱
- Author:
Chuanzheng SUN
;
Feizhou HUANG
;
Wenguang YAN
;
Huaizheng LIU
;
Changfa WANG
- Keywords:
long non-coding RNA;
non-alcoholic fatty liver disease;
expression profile;
gene chip
- From:
Journal of Central South University(Medical Sciences)
2017;42(7):741-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the characteristics of long non-coding RNA (lncRNA) expression in nonalcoholic fatty liver disease (NAFLD).Methods:lncRNA-mRNA microarray was conducted on the liver tissue samples from 10 patients with simple gallbladder stone (5 NAFLD liver samples and 5 normal liver samples),and the differentially expressed lncRNA was analyzed by bioinformatics technology.Results:Compared with the normal liver samples,there were abnormal expression of 1 735 lncRNAs and 1 485 mRNAs in NAFLD liver samples.Among them,535 lncRNAs and 760 mRNAs were up-regulated,1 200 lncRNAs and 725 mRNAs were down-regulated.Conclusion:Compared with normal liver,the expression oflncRNA in NAFLD tissues is obviously abnormal.These lncRNAs may play an important role in the occurrence and development of NAFLD.
