The Efficacy of Etanercept Combined Leflunomide to Treat Ankylosing Spondylitis and Its Safety
10.13241/j.cnki.pmb.2017.22.021
- VernacularTitle:依那西普联合来氟米特治疗强直性脊柱炎的疗效观察及安全性分析
- Author:
Liangmin CHEN
;
Yong JIANG
;
Lijuan XING
;
Jing WANG
;
Zhihua CHU
;
Jin GAO
;
Jianqiang LI
- Keywords:
Etanercept;
Leflunomide;
Ankylosing spondylitis;
Efficacy;
Safety
- From:
Progress in Modern Biomedicine
2017;17(22):4292-4294,4310
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy of etanercept combined leflunomide to treat ankylosing spondylitis (AS) and its safety.Methods:90 cases with AS patients admitted in our hospital from June 2016 to January 2015 were selected.The patients were divided into observation group and control group by random number table method,45 cases in each group.Observation group was treated with etanercept combined with leflunomide,the control group were treated by leflunomide only.Morning stiffness time,AS activity index (BASDAI),AS measurement index (BASMI) were recorded before and after treatment in two groups,the total effective rate and adverse reaction were compared between the two groups.Results:After treatment,the BASDAI and morning stiffness time,BASMI of two groups of patients compared with before treatment were decreased,and the indexes above of the observation group were significantly lower than the control group,the difference was statistically significant (P＜0.05);The effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant (P＜0.05);During the course of treatment,the main adverse reactions occurred in patients with liver function damage,diarrhea and allergic skin rash,but there was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion:Etanercept combined with leflunomide can obtain ideal effect,and low incidence rate of adverse reaction,it is worth popularizing in clinical use.
