Correlation of Serum Levels of IL-21, TGF-β1, TNF-α and IgA1 in Children with Allergic Purpura and Occurrence of Purpura Nephritis
10.13241/j.cnki.pmb.2017.22.022
- VernacularTitle:过敏性紫癜患儿血清IL-21,TGF-β1,TNF-α及IgA1水平与紫癜性肾炎发生的相关性研究
- Author:
Xinfeng YANG
;
Huirong WANG
;
Hao TIAN
;
Guoming NIE
;
Minshu ZOU
- Keywords:
Allergic purpura;
Purpura nephritis;
Interleukin-21;
Transforming growth factorβ1;
Tumor necrosis factor-α;
Immunoglobulin A1
- From:
Progress in Modern Biomedicine
2017;17(22):4295-4298
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the correlation of serum levels of IL-21,TGF-β1,TNF-α and IgA1 in children with allergic purpura and the purpura nephritis.Methods:57 cases with allergic purpura who were treated in our hospital from November 2015 to May 2016 were selected and 29 cases were diagnosed with general allergic purpura,and another 28 cases were diagnosed with purpuric nephritis.30 healthy children were selected as the control group.Then the serum levels of IL-21,TGF-β1,TNF-α,IgAl,immunoglobulin A (IgA),C3 and C4 between the three groups were observed and compared.Results:The serum levels of IL-21,TGF-β1,TNF-α,IgA1 and IgA in the purpuric nephritis group were higher than those of the control group and the general allergic purpura group,and the differences were statistically significant (P＜0.05);The serum levels of IL-21,TGF-β1,TNF-α,IgA1 and IgA in the general allergic purpura group were higher than those of the control group,and the differences were statistically significant (P＜0.05);There was no statistically significant difference about the C3 and C4 in the three groups (P＞0.05).Conclusion:The serum levels of IL-21,TGF-β1,TNF-α and IgA1 may be involved in the development ofhenoch-schonlein purpura and purpura nephritis.
