Effects of Repetitive Transcranial Magnetic Stimulation Combined with Biofeedback Non Motor Symptoms on Serum Levels of IL-6, CRP and TNF-α in Patients with Parkinson's Disease
10.13241/j.cnki.pmb.2017.22.027
- VernacularTitle:重复经颅磁刺激联合生物反馈疗法对帕金森病患者血清IL-6,CRP及TNF-α水平的影响
- Author:
Chanjuan CHEN
;
Xiaojun YU
;
Dan HE
;
Sixin LIU
;
Jie WU
- Keywords:
Non motor symptoms of Parkinson's disease;
Repetitive transcranial magnetic stimulation;
Biofeedback
- From:
Progress in Modern Biomedicine
2017;17(22):4314-4317
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the Repetitive transcranial magnetic stimulation combined with biofeedback non motor symptoms on clinical effects and serum levels of IL-6,CRP and TNF-α of Parkinson's disease.Methods:84 cases of Parkinson's disease in our hospital were randomly divided into experimental group and control group,with 42 cases in each group.The control group were treated with EMG and EEG biofeedback,while the experimental group were treated with repetitive transcranial magnetic stimulation on the basis of the control group.Then the serum levels of C reactive protein (CRP) and interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α),the non motor symptoms questionnaire (NMSQuest),Parkinson's disease Sleep Scale (PDSS) and Hamilton Depression Scale (HAMD) score in the two groups were observed and compared before and after the treatment.Results:Compared with before treatment,the serum levels of CRP,IL-6 and TNF-α,the NMSQuest and HAMD in the two groups decreased after the treatment,while the PDSS score increased,and the differences were statistically significant (P＜0.05);Compared with the control group,the serum levels of CRP,IL-6 and TNF-α,NMSQuest and HAMD in the experimental group were lower,while the PDSS score was higher,and the differences were statistically significant (P＜0.05).Conclusion:Repetitive transcranial magnetic stimulation combined with biofeedback can reduce the serum levels of IL-6,CRP and TNF-α in patients with Parkinson's disease,which has better clinical effect on the non motor symptoms.
